Současné možnosti predikce léčebné odpovědi na neoadjuvantní chemoradioterapii u karcinomu konečníku
Filip Pazdírek1, Marek Minárik Orcid.org 2,3, Lucie Benešová2, Jiří Hoch Orcid.org , Radka Lohynská4
+ Pracoviště
Souhrn
Standardem léčby pacientů s lokálně pokročilým karcinomem konečníku je neoadjuvantní chemoterapie v kombinaci s radiací. Hlavním cílem léčby je snížit riziko rekurence. S léčbou však mohou být spojeny také závažné nežádoucí účinky v důsledku postradiačního poškození v oblasti pánve. Mnoho skupin se snaží najít markery, které by umožňovaly předpovídat odpověď na léčbu. Tento přehledový článek přináší rešerši literatury provedenou za účelem identifikace hlavních studií zaměřených na použití klinických, radiologických, imunologických a molekulárních (proteinových, DNA a RNA) markerů. Pro každou skupinu předkládáme souhrn poznatků. Obecně lze shrnout, že interpretace v současné době získaných poznatků je spojena s určitou mírou nejednoznačnosti a nejednotnosti. Zdá se, že i v nejslibnější oblasti cirkulujících molekulárních biomarkerů je zapotřebí dalšího výzkumu, než bude možné stanovit jejich užitečnost v klinické praxi.
Klíčová slova
karcinom konečníku, neoadjuvantní chemoradioterapie, cirkulující nádorová ctDNA, prognóza, odpověď, biomarkerČlánek je v angličtině, prosím přepněte do originální verze.
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Literatura
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