Gastroenterologie
a hepatologie

Magnesium sulfate saline laxatives in the preparation for colonoscopy – our experience

Sylvia Dražilová¹, Ján Lietava ^{Orcid.org  2}, Pavol Borecký ^{Orcid.org  3}

+ Affiliation
¹ Oddelenie vnútorného lekárstva s JIS metabolickou, Nemocnica Poprad, a. s., Slovenská republika
² I. interná klinika LFUK a UN Bratislava
³ Špecializovaná geriatrická nemocnica Podunajské Biskupice, UN Bratislava, Slovenská republika

Summary

Aim: To assess the efficacy of and tolerance to the new saline laxative F.X. Passage® SL with 30% magnesium sulfate for colonoscopy preparation and to compare it with the standard preparation consisting of sodium picosulfate and magnesium citrate. Methodology: This was an open, comparative, randomised, unblind, prospective study. All patients were treated at the Gastroenterological Outpatient Service of the Department of Internal Medicine of Hospital Poprad between November, 2015, and December, 2016. A total of 91 and 61 patients received the magnesium sulfate and standard preparations, respectively. Basic characteristics, presence of gastrointestinal diseases, comorbidities and medications taken were comparable in the two groups. Bowel cleansing was assessed using the Boston Bowel Preparation Scale (BBPS). Results: The mean BBPS score for the whole colon was significantly higher in the magnesium sulfate group (7.70 ± 1.19) than in the standard preparation group (7.19 ± 1.32; p=0.013). The same significant difference was observed in single segments (right colon and transverse colon). Both regimens were tolerated and effective in patients suffering from obstipation. Compliance, especially with the drinking regime, was better in the magnesium sulfate group than in the standard preparation group. Although adverse effects (mostly nausea and vomiting) were more frequent in the magnesium sulfate group than in the standard preparation group, no patient suffered a serious adverse effect. Conclusions: Magnesium sulfate was superior to sodium picosulfate and magnesium citrate for effective colon cleansing. Although the magnesium sulfate preparation was associated with a significantly higher number of adverse events, this was not a limitation for the colonoscopy procedure.

Keywords

Boston Bowel Preparation Scale, colonoscopy, magnesium sulfate, laxatives

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