Primary gastric adenocarcinoma with yolk sac differentiation
Zdeněk Diviš1, Ondřej Lukáš1, Jan Laco2, Marcela Kopáčová Orcid.org 3
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Summary
We present the case of a 41-year-old patient who was brought to our hospital because of suspected bleeding into the upper part of gastrointestinal tract. Gastroscopy found an ulcerated infiltration at the posterior wall of the subcardial stomach. Histological analysis showed the presence of an adenocarcinoma of the stomach with yolk sac differentiation, which is a rare type of malignant tumor with a poor prognosis that has usually metastasized to secondary sites such as the liver at the time of diagnosis.
Keywords
adenocarcinoma, yolk sac tumor, stomachTo read this article in full, please register for free on this website.
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Literature
1. International Agency for Research on Cancer. World Health Organization. GLOBOCAN 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. [online]. Available from: http: //globocan.iarc.fr/Pages/fact_sheets_cancer.aspx?cancer=stomach.
2. Epidemiologie zhoubných nádorů v České republice. [online]. Dostupné z: www.svod.cz.
3. Obermannová R, Novák J, Novotný I et al. Multidisciplinární přístup v diagnostice a léčbě karcinomu žaludku. Gastroent Hepatol 2013; 67 (5): 390–395.
4. Rejchrt S. Endoskopická léčba premalignit a časných malignit GIT. Česká společnost HPB chirurgie 2002; 2 (4): 19–21.
5. Hong R, Hong Suh C, Lee MJ. Adenocarcinoma with yolk sac tumor of the stomach: case report with review of the literature and an immunohistochemical study. Korean J Pathol 2007; 41 (5): 352–357.
6. Kim YS, Kim SH, Seong JK et al. Gastric yolk sac tumor: a case report and review of the literature. Korean J Intern Med 2009; 24 (2): 143–146. doi: 10.3904/kjim.2009.24.2.143.
7. Lunghi A, Petreni P, Romanelli RG et al. Aggresive gastric carcinoma producing alpha-fetoprotein: a case report and review of the literature. Case Rep Oncol 2014; 7 (1): 92–96. doi: 10.1159/000358509.
8. Singh M, Arya M, Anand S et al. Gastric adenocarcinoma with features of endodermal sinus tumor. World J Gastroenterol 2007; 13 (35): 4781–4783.
9. Magni E, Sonzogni A, Zampino MG. Primary pure gastric yolk sac tumor. Rare Tumours 2010; 2 (1): e10. doi: 10.4081/rt.2010.e10.
10. Vivekanandarajah A, Atallah JP, Gupta S. Alpha-fetoprotein-producing nonmetastatic gastric adenocarcinoma: a rare entity. J Gastrointest Cancer 2014; 45 (2): 225–227. doi: 10.1007/s12029-013-9498-2.
11. Yang J, Wang R, Zhang W et al. Clinicopathological and prognosis characteristic of hepatoid adenocarcinoma of the stomach. Gastroenterol Res Pract 2014; 2014: 140587. doi: 10.1155/2014/140587.
12. Li L, Zhang WH, Meng FP et al. Gastric metastasis of hepatocellular carcinoma with gastrointestinal bleeding after liver transplant: a case report. Transplant Proc 2015; 47 (8): 2544–2547. doi: 10.1016/j.transproceed.2015.09.012.
13. Nogales FF, Preda O, Nicolae A. Yolk sac tumours revised. A review of their many faces and names. Histopatology 2012; 60 (7): 1023–1033. doi: 10.1111/j.1365-2559.2011.03889.x.
14. Chun H, Kwon SJ. Clinicopathological characteristic of alpha-fetoprotein-producing gastric cancer. J Gastric Cancer 2011; 11 (1): 23–30. doi: 10.5230/jgc. 2011.11.1.23.
15. Garcia RL, Ghali VS. Gastric choriocarcinoma and yolk sac tumor in a man: observations about its possible origin. Hum Pathol 1985; 16 (9): 955–958.
16. Matoyama T, Saito K, Iwafuchi M et al. Endodermal sinus tumor of the stomach. Acta Pathol Jpn 1985; 35 (2): 497–505.
17. Zámečník M, Patriková J, Gomolčák P. Yolk sac carcinoma of the stomach with gastrin positivity. Hum Pathol 1993; 24 (8): 927–928.
18. Suzuki T, Kimura N, Shizawa S et al. Yolk sac tumor of the stomach with an adenocarcinomatous component: a case report with immunohistochemical analysis. Pathol Int 1999; 49 (6): 557–562.
19. Wang L, Tabbarah HJ, Gulati P et al. Gastric adenocarcinoma with a yolk sac component: a case report and review of the literature. J Clin Gastroenterol 2000; 31 (1): 85–88.
20. Puglisi F,Damante G, Pizzolitto S et al. Combined yolk sac tumor and adenocarcinoma in a gastric stump: molecular evidence of clonality. Cancer 1999; 85 (9): 1910–1906.
21. Napaki S. Combined yolk sac tumour and adenocarcinoma of the oesophago-gastric junction. Pathology 2004; 36 (6): 589–592.
22. Kanai M, Torii A, Hamada A et al. Pure gastric yolk sac tumor that was diagnosed after curative resection: case report and review of literature. Int J Gastrointest Cancer 2005; 35 (1): 77–81.
23. Ukiyama E, Endo M, Yoshida F et al. Recurrent yolk sac tumor following resection of a neonatal immature gastric teratoma. Pediatr Surg Int 2005; 21 (7): 585–588.
24. Singh M, Arya M, Anand S et al. Gastric adenocarcinoma with features of endodermal sinus tumor. World J Gastroenterol 2007; 13 (35): 4781–4783.
25. Tahara H, Hirokawa T, Oyama T et al. Gastric yolk sac tumor complicated with betahuman chorionic gonadotropin- -producing metastases. Intern Med 2008; 47 (24): 2145–2149.
26. Kunin N, Ferrand L, Morreau L et al. Gastric yolk sac tumor. Gastroenterol Clin Biol 2010; 34 (8–9): e11–e13. doi: 10.1016/j.gcb.2010.04.004.
27. Chen CJ, Hsu HT, Yen HH. Anunusual cause of upper gastrointestinal bleeding. Gastric yolk sac tumor with a large retroperitoneal metastasis. Gastroenterology 2010; 139 (4): 1098, 1427. doi: 10.1053/j.gastro.2009.10.060.
28. Satake N, Chikakiyo M, Yagi T et al. Gas- tric cancer with choriocarcinoma and yolk sac tumor components: case report. Pathol Int 2011; 61 (3): 156–160. doi: 10.1111/ j.1440-1827.2010.02635.x.
29. Bihari C, Rastogi A, Chandan KN et al. Gastric adenocarcinoma with yolk sac tumor differentiation and liver metastasis of yolk sac tumor component. Case Rep Oncol Med 2013; 2013: 923596. doi: 10.1155/2013/923596.
2. Epidemiologie zhoubných nádorů v České republice. [online]. Dostupné z: www.svod.cz.
3. Obermannová R, Novák J, Novotný I et al. Multidisciplinární přístup v diagnostice a léčbě karcinomu žaludku. Gastroent Hepatol 2013; 67 (5): 390–395.
4. Rejchrt S. Endoskopická léčba premalignit a časných malignit GIT. Česká společnost HPB chirurgie 2002; 2 (4): 19–21.
5. Hong R, Hong Suh C, Lee MJ. Adenocarcinoma with yolk sac tumor of the stomach: case report with review of the literature and an immunohistochemical study. Korean J Pathol 2007; 41 (5): 352–357.
6. Kim YS, Kim SH, Seong JK et al. Gastric yolk sac tumor: a case report and review of the literature. Korean J Intern Med 2009; 24 (2): 143–146. doi: 10.3904/kjim.2009.24.2.143.
7. Lunghi A, Petreni P, Romanelli RG et al. Aggresive gastric carcinoma producing alpha-fetoprotein: a case report and review of the literature. Case Rep Oncol 2014; 7 (1): 92–96. doi: 10.1159/000358509.
8. Singh M, Arya M, Anand S et al. Gastric adenocarcinoma with features of endodermal sinus tumor. World J Gastroenterol 2007; 13 (35): 4781–4783.
9. Magni E, Sonzogni A, Zampino MG. Primary pure gastric yolk sac tumor. Rare Tumours 2010; 2 (1): e10. doi: 10.4081/rt.2010.e10.
10. Vivekanandarajah A, Atallah JP, Gupta S. Alpha-fetoprotein-producing nonmetastatic gastric adenocarcinoma: a rare entity. J Gastrointest Cancer 2014; 45 (2): 225–227. doi: 10.1007/s12029-013-9498-2.
11. Yang J, Wang R, Zhang W et al. Clinicopathological and prognosis characteristic of hepatoid adenocarcinoma of the stomach. Gastroenterol Res Pract 2014; 2014: 140587. doi: 10.1155/2014/140587.
12. Li L, Zhang WH, Meng FP et al. Gastric metastasis of hepatocellular carcinoma with gastrointestinal bleeding after liver transplant: a case report. Transplant Proc 2015; 47 (8): 2544–2547. doi: 10.1016/j.transproceed.2015.09.012.
13. Nogales FF, Preda O, Nicolae A. Yolk sac tumours revised. A review of their many faces and names. Histopatology 2012; 60 (7): 1023–1033. doi: 10.1111/j.1365-2559.2011.03889.x.
14. Chun H, Kwon SJ. Clinicopathological characteristic of alpha-fetoprotein-producing gastric cancer. J Gastric Cancer 2011; 11 (1): 23–30. doi: 10.5230/jgc. 2011.11.1.23.
15. Garcia RL, Ghali VS. Gastric choriocarcinoma and yolk sac tumor in a man: observations about its possible origin. Hum Pathol 1985; 16 (9): 955–958.
16. Matoyama T, Saito K, Iwafuchi M et al. Endodermal sinus tumor of the stomach. Acta Pathol Jpn 1985; 35 (2): 497–505.
17. Zámečník M, Patriková J, Gomolčák P. Yolk sac carcinoma of the stomach with gastrin positivity. Hum Pathol 1993; 24 (8): 927–928.
18. Suzuki T, Kimura N, Shizawa S et al. Yolk sac tumor of the stomach with an adenocarcinomatous component: a case report with immunohistochemical analysis. Pathol Int 1999; 49 (6): 557–562.
19. Wang L, Tabbarah HJ, Gulati P et al. Gastric adenocarcinoma with a yolk sac component: a case report and review of the literature. J Clin Gastroenterol 2000; 31 (1): 85–88.
20. Puglisi F,Damante G, Pizzolitto S et al. Combined yolk sac tumor and adenocarcinoma in a gastric stump: molecular evidence of clonality. Cancer 1999; 85 (9): 1910–1906.
21. Napaki S. Combined yolk sac tumour and adenocarcinoma of the oesophago-gastric junction. Pathology 2004; 36 (6): 589–592.
22. Kanai M, Torii A, Hamada A et al. Pure gastric yolk sac tumor that was diagnosed after curative resection: case report and review of literature. Int J Gastrointest Cancer 2005; 35 (1): 77–81.
23. Ukiyama E, Endo M, Yoshida F et al. Recurrent yolk sac tumor following resection of a neonatal immature gastric teratoma. Pediatr Surg Int 2005; 21 (7): 585–588.
24. Singh M, Arya M, Anand S et al. Gastric adenocarcinoma with features of endodermal sinus tumor. World J Gastroenterol 2007; 13 (35): 4781–4783.
25. Tahara H, Hirokawa T, Oyama T et al. Gastric yolk sac tumor complicated with betahuman chorionic gonadotropin- -producing metastases. Intern Med 2008; 47 (24): 2145–2149.
26. Kunin N, Ferrand L, Morreau L et al. Gastric yolk sac tumor. Gastroenterol Clin Biol 2010; 34 (8–9): e11–e13. doi: 10.1016/j.gcb.2010.04.004.
27. Chen CJ, Hsu HT, Yen HH. Anunusual cause of upper gastrointestinal bleeding. Gastric yolk sac tumor with a large retroperitoneal metastasis. Gastroenterology 2010; 139 (4): 1098, 1427. doi: 10.1053/j.gastro.2009.10.060.
28. Satake N, Chikakiyo M, Yagi T et al. Gas- tric cancer with choriocarcinoma and yolk sac tumor components: case report. Pathol Int 2011; 61 (3): 156–160. doi: 10.1111/ j.1440-1827.2010.02635.x.
29. Bihari C, Rastogi A, Chandan KN et al. Gastric adenocarcinoma with yolk sac tumor differentiation and liver metastasis of yolk sac tumor component. Case Rep Oncol Med 2013; 2013: 923596. doi: 10.1155/2013/923596.