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Gastroenterologie
a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2020; 74(2): 148–153. doi:10.14735/amgh2020148.

Position of vedolizumab in the current treatment of Crohn’s disease

Pavel Drastich Orcid.org  1

+ Affiliation

Summary

Vedolizumab (VDZ) is a gut-selective anti-integrin monoclonal antibody indicated for the treatment of patients with moderate and severe Crohn’s disease, who have failed conventional or anti-tumour necrosis factor a therapies. The main objectives in Crohn’s disease are to avoid disease complications and preserve the patient’s quality of life. Clinical trials and real-life data have shown that VDZ is effective and safe for the treatment of Crohn’s disease patients. The objective of this article is to present new data and answer practical questions regarding the role of VDZ in the therapy of Crohn’s disease.

Key words: Crohn’s disease – vedolizumab – anti-integrin therapy

Keywords

Crohn’s disease, vedolizumab, antiintegrinová léčba

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