Gastroenterologie
a hepatologie

Obesity in children and kidney diseases

Zlatko Marinov¹, Cecília Marinová²

+ Affiliation
¹ Dětská obezitologická ambulance FN Motol, Praha
² Medasol s.r.o., Praha

Summary

Chronic kidney disease and non-alcoholic fatty liver disease are global public health concerns. Diabetes, hypertension, and obesity are risk factors for and major contributors to these diseases. Common obesity is frequent in developed countries and is accompanied by chronic metabolic changes. Adipose tissue is the largest endocrine organ in the body, and expansion of this organ results in gradual but extensive cardiometabolic changes due to insulin resistance, proinflammatory status, and endothelial dysfunction, with irreversible central dysregulation of energy homeostasis. The renal and liver effects of common obesity may have their origins in childhood overweight.

Keywords

chronic kidney disease, children obesity, cardiometabolic risk, non-alcoholic fatty liver disease, programming

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