Gastroenterologie
a hepatologie

New perspectives on pharmacotherapy in the algorithm of colorectal cancer liver metastases management

Miroslav Ryska¹, Zdeněk Krška ^{Orcid.org  2}, Jiří Pudil ^{Orcid.org  3}, Patrik Georgiev ^{Orcid.org  4}, Luboš Petruželka ^{Orcid.org  5}, Michal Vočka ^{Orcid.org  5}

+ Affiliation
¹ Chirurgická klinika 2. LF UK a ÚVN – VFN v Praze
² I. chirurgická klinika 1. LF UK a VFN v Praze
³ Chirurgická klinika 2. LF UK a ÚVN Praha
⁴ Onkologická klinika 1. LF UK a VFN – ÚVN Praha
⁵ Onkologická klinika 1. LF UK a VFN v Praze

Summary

Neoadjuvant systemic pharmacotherapy has the potential to convert initially unresectable metastases to resectable ones. The exact criteria for patient selection, optimum therapeutic regime and duration of neoadjuvant therapy, including the timing of surgical intervention, depend on many factors related to the patient (performance status, co-morbidities, etc.) and to the disease (extent and localization of metastases, synchronous vs metachronous form, etc.). The real conversion rate is likely to be low.
 

Keywords

liver metastases, colorectal cancer, conversion, treatment

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