Matrix metalloproteinases and their inhibitors in correlation to proliferative and classical tumour markers during surgical therapy of colorectal liver metastases
Václav Liška Orcid.org , Vladislav Třeška Orcid.org 1, Alan Sutnar Orcid.org , Luboš Holubec Orcid.org 2,3, Tomáš Skalický Orcid.org , Martin Pešta Orcid.org 3, Stanislav Kormunda Orcid.org , Jindřich Fínek Orcid.org 2, Milena Roušarová Orcid.org 2, Ondřej Topolčan Orcid.org 3
+ Affiliation
Summary
Introduction: A proliferative tumour markers and matrix metalloproteinases and their tissue inhibitors reflect the features of malignancy and they have a role in prognosis prediction in patients with colorectal metastases (CLM) in the liver. Their physiological functions during liver regeneration is not comptelety known. Methods: Only patients those had been operated in our department between 11/2002 and 12/2004 were included. They underwent the following surgical procedures: Group (control) A: 22 patients with groin hernias, Group B: 26 patients with benign liver lesions, Group C: 30 CLM patients were treated by radiofrequency ablation, Group D: 41 patients with CLM those underwent radical liver surgery and Group E: 22 patients with inoperable CLM those underwent explorative laparotomy only. The preoperative and postoperative serum levels of CEA, CA19-9, K, TPA, TPS, MMP-2, MMP-9, TIMP-1 and TIMP-2 were measured. Results: We proved a asignificat differences of serum levels MMP-2, -9; TIMP-2 and TPS, TK, MMP-2, TIMP-2 in a preoperative and postoperative settings respectively between control Group A and Group B. The comparison of control Group A and Group C displayed a significant differences in the preoperative serum levels of TPA, TPS, MMP-2, TIMP-2, CEA and CA19-9 and postoperative serum levels of TK, TPA, TPS, TIMP-1, -2, CEA, CA19-9 respectively. The comparison of control Group A and Group D demonstrated a significant diferences in the preoperative serum levels of TPA, TPS, MMP-2 and -9, TIMP-1, -2, CEA, CA19-9 and postoperative serum levels of TK, TPA,TPS, MMP-9, TIMP-1, -2, CEA, CA19-9 respectively. The comparison of control Group A with Group E proved a significant differences in the preoperative serum levels of TK, TPA, TPS, MMP-2 and -9, TIMP-1, -2, CEA, CA19-9 and postoperative serum levels of TK, TPA, TPS, MMP-2, TIMP-1, -2, CEA, CA19-9 respectively. Conclusion: The retrospective analysis of serum matrix metalloproteinases and their tissues inhibitors in differenet group of patients has shown that serum levels of tumour markers are influenced significantly due to the regeneration and remodelling of healing tissues. The study findings support a critical view how to use these tumour markers for disease prognosis prediction in patients after surgical procedure for CLM.
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