Gastroenterologie
a hepatologie

Filgotinib in ulcerative colitis in clinical practice: real-world data published in 2025

Milan Lukáš¹, Martin Lukáš jr.¹

+ Affiliation
¹ Klinické a výzkumné centrum pro střevní záněty, Klinické centrum ISCARE a. s. a 1. LF UK v Praze

Summary

Filgotinib is a preferential JAK-1 inhibitor, which was introduced in clinical practice in ulcerative colitis patients in 2022. In that year, many real-world clinical data have been published, documenting that filgotinib therapy is associated with high efficacy and safety. The most important project in real clinical practice is the GALOCEAN study, from which the first preliminary data have been presented. Clinical practice confirmed that the anti-inflammatory efficacy of filgotinib is similar to tofacitinib, but slightly lower than upadacitinib. Compared to upadacitinib and tofacitinib, long-term therapy with filgotinib is associated with a lower frequency of side effects.

Keywords

filgotinib, ulcerative colitis, JAK inhibitors, upadacitinib, tofacitinib

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