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a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2020; 74(4): 334–338. doi:10.14735/amgh2020334.

Whipple disease – two case reports

Jarmila Šurinová1, Ludvík Straka1

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We present two cases of our patients examined for weight loss, arthralgia and diarrhea, who were diagnosed with Whipple disease. Whipple disease is a rare chronic systemic illness, nevertheless it can be found in the ordinary clinical practice. Symptoms of this disease are not generally specific ones. The diagnosis is based on gastroscopic findings of duodenal mucosal atrophy with enlarged lymphatics, typical histological findings and polymerase chain reaction verification of Tropheryma whipplei. If we consider the disease in the differential diagnosis, an antibiotic treatment is almost always successful. To reduce the risk of relapse, such treatment should be carried out on a long-term basis.

Key words: Whipple disease – endoscopy – malabsorption syndromes – Tropheryma whipplei


Whippleova choroba, endoscopic treatment, malabsorption syndrome, Tropheryma whipplei

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