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Gastroenterologie
a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2015; 69(3): 201–203. doi:10.14735/amgh2015201.

Torpid herpetic esophagitis in immunocompetent patient – video case report

Ivana Mikoviny Kajzrlíková1, Alžběta Buriánová2, Vladimír Jr. Hořava3, Petr Vítek4,5, Petr Širůček6

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Summary

We present a case of a 49‑year‑old immunocompetent woman with relapsing and prolonged herpes esophagitis that presented with odynophagia and weight loss. Endoscopy revealed esophageal ulcers with typical morphology, other infectious and non‑infectious causes of esophagitis were excluded. Acyclovir therapy had only transient effect. Long term valacyclovir therapy led to relief of symptoms, esophageal ulcers healed. Direct detection of HSV with PCR was not successful.

Keywords

esophagitis, herpes simplex virus, valacyklovir


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Literature

1. McBane RD, Gross JB Jr. Herpes esophagitis: clinical syndrome, endoscopic appearance, and diagnosis in 23 patients. Gastrointest Endosc 1991; 37 (6):  600–603.
2. Ramanathan J, Rammouni M, Baran J Jr et al. Herpes simplex virus esophagitis in the immunocompetent host: an overview. Am J Gastroenterol 2000; 95 (9): 2171–2176.
3. Baehr PH, McDonald GB. Esophageal infections: risk factors, presentation, diag- nosis, and treatment. Gastroenterology 1994; 106 (2): 509–532.
4. Frobert E, Ooka T, Cortay JC et al. Herpes simplex virus thymidine kinase mutations associated with resistance to acyclovir: a site‑directed mutagenesis study. Antimicrob Agents Chemother 2005; 49 (3): 1055–1059.
5. Levin MJ, Bacon TH, Leary JJ. Resistance of herpes simplex virus infections to nucleoside analogues in HIV‑infected patients. Clin Infect Dis 2004; 39 (Suppl 5): S248–S257.

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