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Gastroenterology and Hepatology

Gastroent Hepatol 2021; 75(3): 252–256. doi: 10.48095/ccgh2021252.

Teduglutide in the treatment of short bowel syndrome in Crohn’s disease

Laura Gombošová  1, Juraj Krivuš2

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Crohn’s disease is an immune-mediated chronic progressive inflammation of the gastrointestinal tract. Many patients require repeated surgeries, 8.6% may develop short bowel syndrome. Short bowel syndrome is a rare diagnosis. Home parenteral nutrition via long-term central venous catheter is the standard of care. Teduglutide a is recombinant analogue of intestinal glucagon-like peptide 2 (GLP2). It is approved for treatment of the short bowel syndrome, it induces intestinal adaptation and increases its resorption capacity. The effect of the treatment is to reduce the volume of parenteral substitution to complete weaning from PN and induction of intestinal autonomy. The review article deals with short bowel syndrome in Crohn’s disease treated with GLP2 analogue.


Crohn’s disease, home parenteral nutrition, intestinal failure, short bowel syndrome, teduglutid, glukagón like peptide 2

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