Severe disease progression of corticosteroid dependent ulcerative colitis in a young child before the era of biological therapy
Kristýna Zárubová1, Jiří Bronský Orcid.org 2, Katarína Mitrová Orcid.org 3,4
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Summary
Colectomy is a treatment option in ulcerative colitis (UC) management in patients with severe UC or pharmacotherapy failure. We present a case of a young patient with severe and corticosteroid dependent UC that was going to be treated with colectomy. However, before deciding to perform the surgery, we successfully used treatment with infliximab, although it was not commonly used in this indication at that time.
Keywords
infliximab, childhood, colectomy, steroid-dependency, ulcerative colitis
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Literature
1. Mamula P, Markowitz JE, Cohen LJ et al. Nfliximab in pediatric ulcerative colitis: two‑year follow‑up. J Pediatr Gastroenterol Nutr 2004; 38 (3): 298–301.
2. Turner D, Mack D, Leleiko N et al. Severe pediatric ulcerative colitis: a prospective multicenter study of outcomes and predictors of response. Gastroenterology 2010; 138 (7): 2282–2291. doi: 10.1053/j.gastro.2010.02.047.
3. Aloi M, D’Arcangelo G, Capponi M et al. Managing paediatric acute severe ulcerative colitis according to the 2011 ECCO‑ESPGHAN guidelines: Efficacy of infliximab as a rescue therapy. Dig Liver Dis 2015; 47 (6): 455–459. doi: 10.1016/j.dld.2015. 01.156.
4. Diamanti A, Knafelz D, Panetta F et al. Thalidomide as rescue therapy for acute severe ulcerative colitis. Eur Rev Med Pharmacol Sci 2014; 18 (12): 1690–1693.
5. Turner D, Levine A, Kolho KL et al. Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: a preliminary report. J Crohns Colitis 2014; 8 (11): 1464–1470. doi: 10.1016/j.crohns.2014.05.010.
6. Aloi M, D‘Arcangelo G, Pofi F et al. Presenting features and disease course of pediatric ulcerative colitis. J Crohns Colitis 2013; 7 (11): e509–e515. doi: 10.1016/j.crohns.2013.03.007.