Gastroenterologie
a hepatologie

Prevalence of hypovitaminosis D and impaired glucose tolerance in patients with neuroendocrine tumours undergoing somatostatin analogues therapy

Lenka Nosáková¹, Peter Bánovčin ^{Orcid.org  2}, Rudolf Hyrdel ^{Orcid.org  3}, Miroslav Pindura⁴, Peter Uhrík³

+ Affiliation
¹ Interná klinika gastroenterologická JLF UK a UN Martin
² Klinika detí a dorastu JLF UK a UN Martin
³ Interná klinika gastroenterologická JLF UK a UN Martin, Slovenská republika
⁴ Chirurgická klinika a transplantačné centrum JLF UK a UN Martin, Slovenská republika

Summary

Introduction:
Neuroendocrine tumors of the gastrointestinal tract (GEP-NETs) are rare tumors representing a heterogeneous group of tumors. Somatostatin analogs (SSA) are commonly used in the palliative treatment of GEP-NETs. The aim of the study was to determine the potential side effects of SSA treatment.
Methods and group of patients:
The set consisted of patients undergoing the treatment with somatostatin analogues in an outpatient form. We evaluated the data about disease duration, SSA treatment, and type of SSA preparation. Subsequently, patients underwent vitamin D and blood glucose tests.
Results:
We evaluated a total of 16 patients (8 women and 8 men). The mean age was 61 years   (43–82 years). Hypovitaminosis D was present in 13 patients (81.25%). Vitamin D levels ranged from 12.2 to 55.8 ng/ml. Glucose tolerance impairment was present in 44% of patients. Blood glucose ranged from 4.5 mmol/l to 7.6 mmol/l.
Conclusion:
Somatostatin analogues are generally considered as safe and well tolerated. In our work, we pointed to the relatively high prevalence of hypovitaminosis D and impaired fasting glucose.

Keywords

neuroendocrine tumors, somatostatin analogues, hypovitaminosis D, glycemia

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