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a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2014; 68(5): 424–429 . doi:10.14735/amgh2014424.

New perspectives on pharmacotherapy in the algorithm of colorectal cancer liver metastases management

Miroslav Ryska1, Zdeněk Krška  2, Jiří Pudil  3, Patrik Georgiev  4, Luboš Petruželka  5, Michal Vočka  5

+ Affiliation


Neoadjuvant systemic pharmacotherapy has the potential to convert initially unresectable metastases to resectable ones. The exact criteria for patient selection, optimum therapeutic regime and duration of neoadjuvant therapy, including the timing of surgical intervention, depend on many factors related to the patient (performance status, co-morbidities, etc.) and to the disease (extent and localization of metastases, synchronous vs metachronous form, etc.). The real conversion rate is likely to be low.


liver metastases, colorectal cancer, conversion, treatment

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