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a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2016; 70(1): 45–50. doi:10.14735/amgh2016csgh.info02.

Immunopatological complications of anti-TNF-α biological treatment

Karin Malíčková  1,2

+ Affiliation


Biological treatment with therapeutic monoclonal antibodies against TNF-α is very effective and safe, and its side effects are usually mild and easily treatable. However, it may sometimes be associated with severe acute and chronic side effects, resulting  from secondary immunopathologie induced by TNF-α blockade. Among the most frequent are eyrly and delayed hypersensitivity ractions to therapeutic immunoglobulin and reactions associated with the induced imbalance of the immune system. Consequences of a cytokine imbalance or antigenic cross-reactivity are significatnly rarer. This paper provides an overview and classification of immunopathological complications of anti-TNF-α blockers.


TNF-alfa, adalimumab, inflammatory bowel disease, infliximab

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