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Gastroenterology and Hepatology

Gastroent Hepatol 2020; 74(6): 469–480. doi: 10.48095/ccgh2020469.

Eosinophilic esophagitis – 10 years of experience in five Czech pediatric endoscopy centers

Jakub Pecl1, Eva Karásková2, Lumír Kunovský3,4, František Jimramovský1, Helena Schneiderová1, Tereza Pinkasová1, Markéta Veverková1, Martin Jouza1, Eliška Hloušková1, Kateřina Bajerová1, Vendula Látalová2, Mária Véghová-Velgáňová2, Miloš Geryk2, Astrid Šuláková5, Lenka Ťoukálková6, Damjan Jakšič6, Martin Zimen7, Marta Ježová3, Milan Urík8, Markéta Wiesnerová9, Petr Jabandžiev1

+ Affiliation



Eosinophilic esophagitis (EoE) is a chronic, progressive inflammatory disease of the esophagus characterized by local eosinophilic infiltration accompanied by symptoms of esophageal dysfunction. The aim of this study was to characterize features of EoE dia gnosed regionally and to describe local strategies for its treatment.


The observational survey retrospectively analyzed a data set of child patients with histologically proven EoE from five pediatric endoscopy centers. This analysis focused on describing their general situation (age, gender, symptoms) and also aimed to investigate any possible linkage between age and symptoms or length of dia gnosis period. Demographic features; clinical symptoms; laboratory, endoscopic, and histopathological findings; and chosen treatment of patients were recorded and analyzed.


From January 2010 to September 2020, 33 new cases of EoE were reported. Strong association of EoE with male sex is consistent with the results from formerly published studies (81.8%). The median age of symptom onset was 7 years, while the median age for dia gnosis was almost 13 years. The most common symptoms were reflux symptoms in general (39.4%), followed by vomiting (36.4%), and dysphagia (33.3%). Examination for sensitization to food allergens was performed on 23 (69.7%) patients with dia gnosed EoE. Out of these, 17 (51.5% of all cases) were found to be sensitive to some allergens. Most of this subgroup (and 48.5% of all cases) were examined by specific IgE testing, and just 2 (6.1% of all cases) patients were tested only by skin prick tests. Another allergic comorbidity was present in 75.8% of patients, and the most common of these were bronchial asthma and allergic rhinoconjunctivitis (45.5% and 42.2%, respectively). More than two-thirds of patients (69.7%) had abnormal macroscopic findings during dia gnostic endoscopy, and the most common were longitudinal furrows and white exudates. The most common initial modality of treatment was to use proton-pump inhibitors (PPI; 93.9%), followed by food elimination (75.8%) and then by corticosteroid administration (63.6%). The vast majority of patients treated with corticosteroids received a topical preparation (90.9%).


This is the first retrospective study on pediatric patients with EoE in the Czech Republic. We found similar features of EoE as reported in formerly published works elsewhere. Collecting long-term prospective observational data in a national EoE register of patients in the Czech Republic would significantly improve our knowledge of this disease.


eosinophilic esophagitis, children, pediatrics, endoscopy


Eosinophilic esophagitis (EoE) is a chronic progressive inflammatory disease characterized by local eosinophilic infiltration of the esophageal mucosa and symptoms resulting from its dysfunction. EoE and gastroesophageal reflux disease (GERD) are today the most commonly identified esophageal causes of difficulty in swallowing among children and adolescents [1]. EoE is currently a relatively common finding in esophagoscopy (up to 7%) and can no longer be considered rare (overall prevalence 0.5–1 case per 1,000 persons) [2]. Despite the number of publications ana lyzing various attributes of EoE, the cause of the exponential increase in its prevalence within Western Europe over the past three decades remains unclear. This is the first retrospective analysis of pediatric EoE in the Czech Republic. The aims of this study were to analyze the demographic, clinical, laboratory, and endoscopic features of pediatric EoE from a large geographic region, to better understand EoE across a wide range of variable manifestations, and to provide feedback to improve the diagnostic-therapeutic process.

Material and methods

The data for patients with the EoE diagnosis were collected from three university hospitals in Moravia and two regional pediatric departments that are capable of endoscopic examinations and further to look after patients with EoE. All participating pediatricians, pediatric gastroenterologists, and allergologists were sent an e-mail asking them to report all diagnoses of histologically proven pediatric EoE (≥ 15 eosinophils per high-power field [HPF] in a sample of esophageal mucosa with the highest number of eosinophils) made in the previous 10 years. The identities of all cases remained anonymous. Data collected via a standardized questionnaire included patient demogra phics, symptoms, macroscopic and histopathological findings at diagnosis and control endoscopy, therapeutic mana gement, allergic comorbidity, and exa mination of sensitization. The collected data are presented as means or medians, with categorical variables summarized as percentages. The data were analyzed using the SAS and SPSS programs. The threshold for statistical significance of tests used in the analysis was 5%.



We have collected reports from 33 cases of pediatric EoE, 27 of which were for male patients (81.8%) and 6 (18.2%) for female patients. The male-to-female ratio is thus approximately 4: 1.

Clinical symptoms

Mean age for the occurrence of EoE symptoms was 8.05 years (SD 5, median 7.0) and the mean age for diagnosis was almost 11.4 years (SD 4.60, median 12.75). Various presenting symptoms leading up to the diagnosis irrespective of and according to age are described in Tab. 1.

The age of manifestation for each individual presenting symptom of EoE and symptomatic time to diagnosis were established, and these data are summarized in Tab. 2. A median of fewer than 3 years was needed to diagnose EoE in patients with food impaction, vomiting, odynophagia, dysphagia, and abdo minal pain. In cases of reflux symptoms, failure to thrive, and food refusal, however, it took a longer time to be referred and diagnosed. The wide range of symptomatic periods makes it difficult to interpret this data and subsequent collection of data would be appropriate.

Irrespective of patient age, reflux symptoms were the most common and affected more than 39% of all patients with EoE. This was closely followed by vomiting (36%) and dysphagia (33%), then by food impaction and stomach ache. The occurrence of clinical symptoms significantly varied depending on children’s ages at the time of diagnosis (Tab. 3).

The youngest patients (≤ 6 years) most frequently showed a failure to thrive (71%), followed by food refusal (57%), and vomiting (43%). Patients from 7 to 14 years of age most frequently complained about dysphagia (55%), followed by vomiting and food impaction (both around 40%), then by reflux symptoms (just less than one-third). Symptoms of patients above 15 years of age were pretty similar to those of the previous age-related group. Reflux symptoms in general, including cough and pyrosis, were typical (almost 54%) and were followed by dysphagia and impaction (both 38%). Adolescents relatively often also referred to vomiting (31%), stomach ache (30%), and odynophagia (23%).

The overall numbers of symptoms manifested by patients with EoE generally and within age-related groups are shown in Tab. 4.

We also looked at the symptomatic time length in relation to the age of the patients at the time of the first symptoms. The data are depicted graphically in Fig. 1.

Patients were divided into three groups according to their age at occurrence of the first symptoms, and the results are summarized in Tab. 5.

The longest symptomatic period prior to establishing the diagnosis was reported in a boy nearly 18 years old who had intermittent dysphagia, vomiting, and reflux symptoms already from his second year of life. The longest-wai ting girl was at first diagnosed as ha ving an eating disorder. From infancy she showed food refusal and failure to thrive, followed later by esophageal reflux symptoms, regurgitation, and nausea. At age 5 years, she refused to swallow solid parts of food and suffered an aspiration episode in attempting to swallow a berry. At 7 years of age, she underwent esophagogastroduodenoscopy, unfortunately without performance of esophageal bio psy. She was referred to a neuro logist for suspicion of autistic spectrum disorder. Finally, at 10 years of age, due to persisting mild problems like dysphagia and regurgitation, she underwent a control endoscopy which, despite normal macroscopic features of esophageal mucosa, showed histopathological features typical of EoE.

Endoscopic and histopathological findings

Almost one-third of the 33 patients with EoE had normal macroscopic findings during the first endoscopy (30%). Other wise longitudinal furrows (sometimes referred to as “crepe paper-like appearance”), white exudates, and mucosal erythema were the most common findings (30%, 8%, and 7%, respectively). Much less frequently, features of chronic inflammation like trachealization or concentric rings (21%) and esophageal strictures (6%) were apparent upon first bio psy. In comparison with the features more frequently seen, however, these had a stronger tendency to persist even after the administration of treatment. Fig. 2 summarizes the presence of various endoscopic findings apparent during diagnostic and control endoscopy in the 33 patients with EoE.

The typical age of patients and symptomatic time to achieving diagnosis according to the particular endoscopic findings are summarized in Tab. 6. A hypothetical association between the age of patients or symptomatic time to diagnosis with certain endoscopic fin dings was examined using Mann-Whitney U-test, but no significant relationship was proven. On the other hand, due to the low number of specific endoscopic findings, the hypothetical association of specific endoscopic findings with the length of a symptomatic period is not conclusively debunked, and this possibility is indicated in the present data set.

The median intraepithelial eosinophil count (IEE) per high-power field (HPF) in the diagnostic bio psy samples obtained from the esophagus in EoE patients was 51.16/HPF, while in the control samples it was 35.48/HPF. Decrease in local eosino philic inflammation during treatment was significant, and this was also confirmed by Wilcoxon signed-rank test (p-value = 0.0002). Nevertheless, this median value is still more than twice the cutoff.

Allergological evaluation

The median relative eosinophil count in peripheral blood samples of patients with EoE was 5.6% (1.70–30.70) and the median immunoglobulin E (IgE) level was 300 kU/l (24–1,960). Relative eosinophil counts and especially IgE levels were significantly higher in younger patients and there was a significant decreasing trend with higher age. The correlation of both variables with age at diagnosis was significant (IgE: Spearman’s Rho = 0.41, p-value = 0.034; Eosinophils: Spearman’s Rho = −0.37, p-value = 0.037). Sensitization to food allergens was examined in 23 (69.70%) patients overall. Of these, 17 (51.52% of all cases) were found to be sensitive to some of the food allergens. Most of this subgroup of patients – 16 (48.48% of all cases) – were examined by laboratory-specific IgE assessment and only 2 (6.06% of all cases) by skin prick-to-prick testing with native foods. Five (15.15%) of the patients were tested by both methods. Three out of 7 patients (42.86%) from the group of the youn gest children (≤ 6 years of age) were sensitized to some food. In 2 (28.57%) cases sensitivity was to cow’s milk, in 2 cases to eggs, and in 2 cases to peanuts. One patient for each (14.29%) had sensiti vity to soy, gliadin, and wheat. In the patient group aged 7–14 years, 7 (53.85%) were sensitized. The most common sensitization was to proteins of cow’s milk, with 4 cases (30.77%), followed by hazelnuts with 3 cases (23.08%). Wheat, walnuts, peanuts, and eggs sensitized 2 (15.38%) patients each, and apples, potatoes, gliadin, and soy 1 (7.69%) patient each. The oldest group of adolescent patients aged 15 years or older had the highest sensitization rate to food allergens: 8 (61.54%) out of 13 overall. These patients were the most often polysensitized to food allergens. The most common food allergens which sensitized this older group were hazelnuts in 7 (53.85%) patients, closely followed by wheat, peanuts, and apples in 6 (46.15%) patients each. Other allergens sensitized adolescents in much lower numbers. Three (23.08%) adolescent patients were allergic to peppers (in 1 case explicitly spe cified as green peppers), 2 (15.38%) patients reported allergy to either egg, soy, oats, cow’s milk, walnuts, almonds, or rice. Allergy to corn, lupine, lentils, peas, beans, peaches, carrots, rye, barley, and gluten, in general, were reported only in 1 (7.69%) older patient each. An evaluation of patient histories revealed bronchial asthma in 45.5% (n = 15), allergic rhinoconjunctivitis in 42.4% (n = 14), food allergy in 27.3% (n = 9), and atopic dermatitis in 24.2% (n = 8). No additional allergic comorbidity was found in 24.4% of patients with EoE (n = 8).


In the 33 patients with EoE analyzed, the most commonly used therapeutic option consisted of proton-pump inhibitors (PPI), which were used in 31 (93.9%) patients. PPI were followed by some type of elimination diet in 25 (75.8%) patients and then by corticosteroids (CS) admi nistration in 21 (63.6%) patients (Tab. 7). Patients usually received a combination of treatments and the most common was all three of the aforementioned modalities, which was seen in 14 (42.4%) patients. PPI was the only therapeutic option used without any of the others only in 3 (9.1%) patients. The rates of administering the various treatments are summarized in Tab. 7.

PPI were administered in 93.9% of EoE cases in this data set, and we may state that the vast majority of patients used PPI in an appropriate dosage (ave - rage dose 0.9 mg/kg/day, median 1 mg/kg/day, min. 0.2, max 1.5).

In the group of patients who were treated with topical CS more than half of patients (57.1%) got budesonide suspension with an appropriate median dose of 2 mg/day. A minority of patients was treated with swallowed fluticasone MDI with a median dose 200 µg/day (min. 100.0, max. 375.0). Only 3 patients were treated with systemic corticosteroids.

Food elimination was a very common treatment among our patients, with 25 (75.8%) eliminating at least one. The most commonly eliminated food consisted of nuts (by 17 patients).

Although the strict six-food diet (SFD) was observed by only 1 (4.00%) patient, another 4 (16.0%) patients adhered to the diet with the exception of one food from SFD (fish, wheat, or soy). The numbers of patients within our data set eliminating various foods are summarized in Fig. 3.

No esophageal dilation was needed, and only 2 of all patients manifes ted complications from treatment. A 13-year-old boy manifested mycotic esophagitis after budesonide suspension administration and an 8-year-old boy complained about itching throat and intermittent dysphagia after fluticasone treatment, which was impossible to differentiate from the manifestation of disease activity.

The rates of clinical, endoscopic, and histopathological remission achievement by the time of the control endoscopy were investigated, and those results are summarized in Tab. 8.


In the presented study we found the basic demographic data to be consistent with that from similar published case series. We demonstrated the vast majority of patients to be male (81%) and the median age at onset to be 7 years. This only strengthens the reliability and reproducibility of our subsequent findings for the data set of patients representing the typical demography of an EoE population as reported in large cross-sectional surveys elsewhere [3].

The complex EoE immunopathogene sis constituting the background for histopathological changes resulting in various endoscopic features and clinical symptoms is summarized in Fig. 4.

Basically, immunopathological mecha - nisms involved in the pathogenesis of EoE are IgE-mediated and non-IgE-mediated reactions, the latter of which are more delayed at the onset. Immediate allergic reactivity is in connection with an immunoglobulin isotype switch to allergen-specific IgE formation, which is set as a result of a predominant allergenic type 2 T-helpers signalization (at the expense of tolerogenic signaling of type 1 T-helpers). This results in loss of immune tolerance and leads to a process of sensitization to food- and aeroallergens that occurs at various sites (e. g., respiratory tract, skin) [10].

EoE is often associated with atopy and food allergy, so nonspecific allergy mar kers were analyzed in this study (total serum IgE and relative eosinophilia) and these were just slightly higher in patients with EoE than are the reference intervals for pediatric patients. This is in concor dance with recently published data showing an absence of clinical effect of anti-IgE antibody (omalizumab) in patients with EoE and demonstrating that the non-IgE mechanism is the dominant immunopathological mechanism of EoE development [11–13]. Almost three--quarters of patients in the present study had been examined and more than half of those had proven sensitization to food allergens. These findings confirm a strong association between food allergy and EoE reported previously [14]. In the present study, we found that laboratory assessment of specific IgE levels is the predominant method for detecting sensitization to food allergens. The severity of symptoms cannot be predicted by either the specific IgE level or the degree of skin testing positivity, but it was proven previously that the probabi lity of symptom onset is directly related. Considering this fact, the authors consider it important to mention that skin prick-to-prick testing with native food triggers (i.e., cow’s milk, eggs, peanuts, and fish) has been shown in studies to have very high negative predictive value and thus it provides reliable, noninvasive, and relatively low-cost exclusion of IgE-mediated mechanisms in the background of EoE pathogenesis [15]. There were significant differences among proven food allergens in the different age groups. Cow’s milk, eggs, and peanuts were dominant food allergens of children up to 7 years of age. Above this age, tree nuts, wheat, apples, and peanuts rise in significance. These results are quite similar in comparison to those from other, previously published Western studies [16]. These observations are in agreement with the known phenomenon of oral tolerance and disappearance of allergic reactivity in relationship to some food allergens that is common at an early age and with rising relevance of other food allergens that often are homologous with some of the aeroallergens (i.e., Bet v1) [17]. More than one--quarter (27.3%) of the 33 analyzed EoE patients suffered from oral allergy syndrome (sometimes reported as a food-pollen syndrome), which is caused by cross-reactivity of an IgE-mediated immune reaction to specific aeroallergens having proteins similar to those in some fruits, vegetables, or tree-nuts. Large re - trospective surveys have proven a strong association of EoE with commonly seen atopic diseases (most frequently with allergic rhinoconjunctivitis) [3,18]. Furthermore, three-quarters of all patients in the present study showed some allergic comorbidity, with bronchial asthma and/or allergic rhinoconjunctivitis diagnosed in almost half of them. It is noteworthy that statistical analysis of the remission achievement rate in relation to other allergic comorbidities in our 33 patients showed no impact of these comorbidities on the results of the treatment.

Allergic inflammation results in eso phageal dysfunction that is accompanied by clinical symptoms related to the age of the patients. Younger children usually manifest only nonspecific symptoms that have a considerable degree of overlap with symptoms of gastroesophageal reflux. Vomiting, food refusal, and failure to thrive are the most common symptoms of EoE in preschool children. Controversially, abdominal pain in this age group is particularly tricky to interpret. Parents of young children are usually referring about so-called “colics”, and preschool children may also complain of epigastric pain despite having only an esophageal disease with chest pain (odynophagia), dysphagia, or pyrosis (heartburn) [19]. When EoE is chronic, without adequate therapy, and usually progressing, the disease shows many and variable combinations, with symptoms changing through time during childhood. Earlier publications mention these clinical features of EoE as a pitfall of EoE diagnostics, and especially in younger children.

The youngest patients in this survey were two boys who both had manifested difficulty feeding, food refusal in combination with various symptoms of gastroesophageal reflux, and failure to thrive at 6 and 9 months of age. It took more than 5 years – and even almost 13 years in the second case – to achieve an appropriate endoscopic diagnosis of EoE. Our results point to a trend of longer symptomatic time in children having their first symptoms at a younger age, as expected. The correlation between age of first symptoms and length of diagnosis is statistically significant (Spearman’s rho = −0.42, p-value = 0.014), and it is obvious that EoE in young children is usually underdiagnosed.

Moreover, one-third of all of the patients experienced only one of the EoE symptoms, which then led to the decision to perform endoscopic evaluation and histopathological diagnosis. This was unusual in the youngest group of patients, and among those children this occurred only once (in the case of a patient refusing food). The appearance of just one symptom before proceeding to bio psy was observed more often among older patients, and most frequently it was abdominal pain or food impaction that led directly to the diagnosis without demonstrating any additional symptoms. This phenomenon also supports the hypothesis that EoE could be underdiagnosed in young children, as they usually must manifest multiple symptoms to get an appropriate diagnosis. Furthermore, symptoms, such as food impaction, that seem able to lead to diagnosis on their own occur not so frequently in young children, further complicating their reaching a diagnosis of EoE. Nevertheless, the statistical test did not confirm any relationship at the 5% significance level between age at diagnosis and number of symptoms. Older children with dysmotility of the eso phagus usually complain about concrete difficulties like dysphagia, odynophagia, or chest pain, as well as various gastro esophageal reflux symptoms. The relative manifestation rates of various symptoms among patients in the present study quite closely correspond to previously published data [20,21]. If these symptoms of esophageal dysmotility in older children are not diagnosed precisely and on time and then adequately treated they may lead to irreversible remodeling of the esophageal wall and irreversible stricture formation with recurrent food impaction [19,22,23].

The mean duration of symptoms in patients involved in this study was 3.36 (SD 3.87) years and the median 2.25 years with a very wide range of symptomatic time to diagnosis of 0–16.5 years.

Interestingly, the cases of girls with EoE in our study showed an even longer symptomatic period (mean 4.9 years with SD 3.8 and median 4.2 years with range 0–10). Unfortunately, in comparison with data published elsewhere, such long symptomatic intervals before appropriate diagnosis in children are not unusual [22,24].

Endoscopic findings in the present pediatric EoE data set included both inflammatory (erythematous mucosa, linear furrows, and patchy white exudates) and fibrostenotic changes (crepe paper-like appearance of the mucosa, concentric ring-like esophageal changes or strictures). The most common endoscopic findings in the present pediatric patient data set were longitudinal furrows and white exudates, which is in concordance with previously published pediatric data from Western countries [22].

If EoE is not treated adequately and in a timely manner, the chronic inflammation in the esophageal wall develops complications associated with the remodeling process. The concentric rings and esophageal strictures can be seen among adult patients with EoE dominant macroscopic findings [2]. Also in our data set these macroscopic signs were seen with the highest median patient’s age among all findings. The results of retrospective studies have shown that the most important risk factor for esophageal remodeling and stricture formation is late establishment of the diagnosis [25].

Detailed guidelines for the management of EoE in pediatric patients are regu - larly published by the Joint Task Force on Allergy-Immunology Practice Para meters, and the respected professional authorities the European Academy of Allergy and Clinical Immunology (EAACI) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) publish a joint communication covering current knowledge on EoE respecting the rules of evidence-based medicine [1,26]. Management of EoE in children aims for the resolution of clinical symptoms as well as endoscopic and histological remission. Based on individual evaluation as to the severity of clinical manifestations, the results of allergological examinations, and macroscopic findings, a decision among the various treatment modalities is made. Treatment options include PPI, elimination diets, and topical or systemic CS administration, as well as their combinations [27]. Systemic CS are reserved for severe cases where rapid relief of symptoms is required and other treatment has not proven successful. This conservative attitude regarding their use was appa rent also in our data set [28]. Magistraliter prescription of budesonide suspension and swallowing of fluticasone aerosol forms are off-label administrations of these drugs. Jorveza® is a new preparation of topical CS budesonide in an orodispersible tablet that is registered in the Czech Republic to treat adults with eosinophilic esophagitis. In a double-blind, placebo-controlled phase III clinical trial (EOS-1), Jorveza® showed both high safety and efficacy for induction and long-term treatment of EoE in adults. To date, there are no available data concerning Jorveza® administration in the pediatric population, but clinical trials are currently being conducted [29].

An elimination diet is considered as a first-line therapeutic modality for children and adults with EoE and, together with food challenges, these are irreplaceable in the diagnostic approach to food allergies. EoE is a chronic disease by its nature, and gradually progressive esophageal wall remodeling is a long- -term process that allows too many patients to adapt to and thus underestimate the symptoms. From these clinical features of EoE there follows a major limitation upon the use of elimination diets, because to objectively measure the complex therapeutic effect of a diagnostic diet necessitates repeated endoscopy assessment and esophageal bio psies after food challenges. The invasivity of these procedures constitutes the main limitation upon admi nistering individual therapeutic diets in childhood. Unfortunately, strong data suggest that the highest efficiency involves elemental diets (90.8%) in comparison with SFD (72.1%), the four-food diet (53.4%), and allergy skin test result--directed food elimination (45.5%) [30]. All these approaches are recommended for the treatment of EoE under the current guidelines [31]. Nevertheless, in order to achieve the highest possible adherence and maintain the best quality of life, it is appropriate to strive for as much targeted elimination in the diet as is possible, and this must be chosen individually for each patient. Time- and cost-effective procedures may point to recommending a diet eliminating a few of the most allergenic foods (i.e., the four-food diet). Then, in order to increase the effectiveness of the diagnostic diet, the standard approach in the health care facilities of the present authors consists in conducting skin prick-to-prick testing with a huge set of the most allergenic foods, including certain oral allergy syndrome triggers and individually referred food suspects. Their positivity is then quantified by detection of IgE to specific components of allergens in order to increase reproducibility and clinical relevance of these results [7,32].

In comparison with a recent meta-analysis, our study showed a slightly lower rate of remission achievement. This may be due to a relatively high proportion of incomplete evaluations, occurring, among other reasons, because some patients did not return for ambulatory controls, a significant number of patients did not undergo control endoscopy and/or bio psy, and the availability of nutritional consulting varied by different health care facility. Moreover, our survey had quite strictly set terms for remission achievement (absence of all symptoms, disappearance of all macroscopic findings, and decrease of IEE strictly below the diagnostic cutoff). Statistical tests were performed to investigate the relationships between certain treatments and rate of remission (clini cal, endoscopic, and histopathological) achievement. Categorical variables and remission achievement were tested using Fisher’s exact test and continuous variables using Mann-Whitney U-test. None of the tested variables (PPI use and its dosage, CS use and its dosage, food elimination, range of food elimi nation, combination of various treatments) proved to be statistically signi ficant. Whereas median IEE count in the control bio psies was still above the diagnostic cutoff, the authors consider it appropriate to mention that local mucosal eosinophilia is not fully pathognomonic and so it may accompany various gastrointestinal diseases (i.e., inflammatory bowel disease) for which differential diagnosis must be borne in mind.

The results of the present analysis are to a great extent consistent with the results of pediatric EoE experience previously published elsewhere, and we claim that the analyzed set of patients truly constitute a representative demographic sample of the regional EoE population.


This study’s comprehensive overview of the present regional management of pediatric EoE may increase pediatricians’ awareness about the characteristics of EoE and may lead to an increase in the frequency of endoscopic verifications and bio psies, especially in younger children often presenting with nonspecific symptoms for a long period. Early detection of EoE and initiation of effective treatment during the inflammatory stage are very important. The therapeutic elimination diet is a safe and reliable approach to the long-term effective management of pediatric patients with EoE. The results of this study are limited by its retrospective design, the relatively small number of patients, and the lack of standardization of the treatment protocols as ensues from the multicenter collection of the analyzed data. The authors would appreciate if this survey would contribute to the founding of a national register of patients with EoE in the Czech Republic.


Figure 4 was created in cooperation with Service Center for e-learning at MU (part of user sup port at IS MU, Faculty of Informatics, Masaryk University, Brno).

Submitted/Doručeno: 2. 10. 2020
Accepted/Přijato: 24. 11. 2020

Petr Jabandžiev, MD, PhD.
Department of Pediatrics
University Hospital Brno
Černopolní 9
613 00 Brno
Czech Republic

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