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a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2016; 70(2): 110– 117. doi:10.14735/amgh2016110.

Chronically elevated levels of liver enzymes

Martin Janičko  1, Eduard Veseliny  1, Peter Jarčuška  1

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The evaluation of increased plasmatic aspartate transaminase, alanine transaminase, γ-glutamyl transpeptidase, and alkaline phosphatase activities is fundamental to a differential diagnosis of liver disease. The correct interpretation of the results of tests for these activities demands much experience. The best option is to use the standardized guidelines to avoid overlooking important pathologies and performing unnecessary tests. Individual patients should be evaluated depending on the urgency of the situation, the timing of the elevation in liver enzymes, and other circumstances. This paper presents a simple recommendation about how to proceed when evaluating elevated liver enzyme levels with respect to evidence-based medicine.


alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, liver diseases, liver tests, γ-glutamyl transferase

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