Anonymous User
Login / Registration

a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2013; 67(1): 17-21.

Assessment of mucosal healing during biological therapy of small bowel Crohn's disease by capsule endoscopy: a prospective observational study

Naděžda Machková  1, Dana Ďuricová  1, Martin Bortlík  1,2,3, Luděk Hrdlička  4,5, Martin Lukáš  1, Milan Lukáš  1

+ Affiliation


Background: Efficacy of anti-TNFα therapy in mucosal healing of Crohn's disease in the small bowel is examined less than in the large bowel due to more difficult detection of mucosal changes.

Aim and methods: The aim of the prospective study was to assess the efficacy of anti-TNFα therapy in mucosal healing of small bowel CD using capsule endoscopy (CE). Patients with CD involving small (+/- large) bowel, who were indicated to anti-TNFα therapy were included.

Results: 25 patients (18 treated with infliximab, 7 with adalimumab) were examined by CE (Mirocam®, IntroMedic, South Korea) at the start of biologic treatment and 19 of them during the maintenance phase of therapy. Mucosal inflammatory changes were assessed by the Lewis score (LS).The median LS at base line was 1,350 (range 337-7,840) with 28% having mild (LS 135-790) and 72% moderate to severe mucosal inflammation (LS > 790). A significant reduction of LS to 402.5 with the range of 0-4,432 (p < 0.001) was observed after median of 32 weeks of treatment, with 83% of patients having only mild mucosal inflammation or normal mucosal finding (LS < 135). Only one (2.3%) capsule retention was observed; other complications were not observed.

Conclusion: Anti-TNFα therapy is effective in mucosal healing of small bowel CD. Capsule endoscopy detected mucosal changes effectively, was well tolerated and relatively safe.


Crohn’s disease, capsule endoscopy, mucosa healing, small intestine

To read this article in full, please register for free on this website.

Benefits for subscribers

Benefits for logged users

Credited self-teaching test