Regulation of transient lower esophageal sphincter relaxation in the pathogenesis of gastroesophageal reflux disease
Martin Ďuriček Orcid.org 1, Martin Schnierer Orcid.org 1
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Summary
Transient lower esophageal sphincter relaxation (TLESR) is a reflexive process allowing swallowed air to be released from the stomach. At the same time, it is also one of the mechanisms participating in the emergence of gastroesophageal reflux. TLESR regulation in humans has been well studied, but there is little information so far on the influence of esophageal stimuli on TLESR development. If TLESR regulation by esophageal stimulation exists, then it is likley to be mediated by afferent esophageal neurons, whose stimulation by refluxate components (e. g. acid) can lead to TLESR dysregulation. The authors are contemplating, within the context of recently published work, the importance of TLESR dysregulation in the pathogenesis of gastroesophageal reflux disease.
Keywords
gastroesophageal reflux, acid, esophagus, transient lower esophageal sphincter relaxationTo read this article in full, please register for free on this website.
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