Gastroenterologie
a hepatologie

Regulation of transient lower esophageal sphincter relaxation in the pathogenesis of gastroesophageal reflux disease

Martin Ďuriček ^{Orcid.org  1}, Martin Schnierer ^{Orcid.org  1}

+ Affiliation
¹ Interná klinika gastroenterologická JLF UK a UN Martin, Slovenská republika

Summary

Transient lower esophageal sphincter relaxation (TLESR) is a reflexive process allowing swallowed air to be released from the stomach. At the same time, it is also one of the mechanisms participating in the emergence of gastroesophageal reflux. TLESR regulation in humans has been well studied, but there is little information so far on the influence of esophageal stimuli on TLESR development. If TLESR regulation by esophageal stimulation exists, then it is likley to be mediated by afferent esophageal neurons, whose stimulation by refluxate components (e. g. acid) can lead to TLESR dysregulation. The authors are contemplating, within the context of recently published work, the importance of TLESR dysregulation in the pathogenesis of gastroesophageal reflux disease.

Keywords

gastroesophageal reflux, acid, esophagus, transient lower esophageal sphincter relaxation

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