Malignant melanoma metastase in the gastrointestinal tract with unknown primary site
Filip Shon1, Marie Kočová2, Zuzana Štiková3
+ Affiliation
Summary
A case of a 73-year-old man with a history of multiple cutaneous tumors treated by surgical excision is presented. The patient was thoroughly followed up by a dermatologist without any sign of recurrence. However, the patient was referred for colonoscopy after showing signs of anorexia and weight loss. Endoscopy and further examination revealed a malignant melanoma with an unknown primary site that had metastasized to the gastrointestinal tract and other organs. The article summarizes information about this aggressive disease, which is one of the most common causes of astrointestinal metastases.
Keywords
endoscopy, melanoma, neoplasm metastasis, gastrointestinal tractTo read this article in full, please register for free on this website.
Benefits for subscribers
Benefits for logged users
Literature
1. SVOD analýza. Incidence a mortalita – vývoj v čase. Brno: Masarykova univerzita 2005. [online]. Dostupné z: www.svod.cz/ analyse.php?modul=incmor#.
2. Panagiotou I, Brountzos EN, Bafaloukos D et al. Malignant melanoma metastatic to the gastrointestinal tract. Melanoma Res 2002; 12(2): 169– 173.
3. Schlagenhauff B, Stroebel W, Ellwanger U et al. Metastatic melanoma of unknown primary origin shows prognostic similarities to regional metastatic melanoma: recommendations for initial staging
examinations. Cancer 1997; 80(1): 60– 65.
4. Liang KV, Sanderson SO, Nowakowski GS et al. Metastatic malignant melanoma of the Gastrointestinal tract. Mayo Clin Proc 2006; 81(4): 511– 516. doi: 10.4065/81.4.511.
5. Lakomý R et al. Současné možnosti léčby pokročilého a metastatického maligního melanomu. Onkologie 2013; 7(2): 65– 68.
6. Hu-Lieskovan S, Robert L, Homet Moreno et al. Combining targeted therapy with immunotherapy
in BRAF-mutant melanoma: promise and challenges. J Clin Oncol 2014; 32(21): 2248– 2254. doi:
10.1200/ JCO.2013.52.1377.
7. Wornom IL 3rd, Smith JW, Soong SJ et al.Surgery as palliative treatment for distant metastases of melanoma. Ann Surg 1986; 204(2): 181– 185.
8. Taal BG, Westerman H, Boot H et al. Clinical and endoscopic features of melanoma metastases in the upper GI tract. Gastrointest Endosc 1999; 50(2): 261– 263.