Guidelines of the Czech Society of Hepatology for diagnosis and treatment of primary biliary cholangitis
Tomáš Fejfar Orcid.org 1, Tomáš Vaňásek Orcid.org 2, Petr Hůlek1,3, Libor Vítek Orcid.org , Soňa Fraňková Orcid.org 4, Radan Brůha Orcid.org 5
+ Affiliation
Summary
Primary biliary cholangitis is a chronic cholestatic disease that is diagnosed based on cholestatic laboratory features, antimitochondrial antibody positivity, or a typical histological pattern. Most patients are asymptomatic at the time of diagnosis. Pruritus and fatigue are the most common symptoms in symptomatic patients. Ursodeoxycholic acid is the first-line therapy. If this fails, the prognosis is unfavorable and second-line therapy can be considered. The associated symptoms must be treated. In advanced disease, liver transplantation should be considered and the complication of portal hypertension must be treated.
Keywords
biliary cholangitis, diagnosis, treatment, primaryLiterature
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