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Gastroenterologie
a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2020; 74(1): 44–49. doi:10.14735/amgh202044.

How to choose the right IBD patients for vedolizumab treatment

Martin Tkáčik1

+ Affiliation

Summary

Currently, there are several types of treatment for inflammatory bowel disease, but it is often difficult to decide on the best treatment. The arrival of new biologics helps us to optimize treatment and improve significantly the course of the disease. Vedolizumab is a monoclonal antibody against integrin α4β7. It is gut selective and inhibits vascular adhesion of leucocytes and their migration to the mucosa of the gut, as well as their interactions with mucosal addresins of the gut wall. It is approved for the treatment of moderate to severe form of ulcerative colitis (UC) and Crohn’s disease. Recent studies confirm higher effectivityhave confirmed it to be more effective and safer than adalimumab (VARSITY clinical trial) in both bionaive and anti-tumor necrosis factor exposed (EVOLVE) patients, with higher clinical and endoscopic remission in patients with UC.

Keywords

anti-TNF, clinical remission, mucosa healing, vedolizumab

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