Anti-TNF alpha-induced immune-mediated skin adverse reactions resolved by switching to ustekinumab
Karolína Vorčáková1, Marta Horáková2, Juraj Péč1
1 Dermatovenerologická klinika JLF UK a UN Martin
2 Gastroenterologická klinika JLF UK a UN Martin
Immune-mediated adverse reactions are a new group of conditions that develop during anti-TNF-alpha treatment. Their etiopathogenesis remains unclear. This study describes three forms of immune-mediated adverse reactions of the skin that were diagnosed correctly. Some types of immune-mediated adverse reactions, such as palmoplantar pustular psoriasis, may persist for a long time after switching biologic agents.
Keywordsanti-TNF-alpha, cutaneous adverse effects, ustekinumab
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