Acute gastrointestinal bleeding and changes in lipid profile - pilot project
Vladimír Hrabovský1, Alice Mendlová, Zdeněk Zadák, Vladimír Bláha2, Radomír Hyšpler, Alena Tichá2, Zdeněk Švagera3
1 Interní klinika LF OU a FN Ostrava
2 Klinika gerontologická a metabolická, FN Hradec Králové
3 Ústav biochemie, FN Ostrava
Purpose of the study: The aim of this pilot study was to describe changes in lipid metabolism in patients with acute gastrointestinal (Gl) bleeding and to assess possible influence of hemodilution and changes in the cholesterol synthesis/absorption process.
Material and methods: In 12 patients with gastrointestinal bleeding, the levels of lipid metabolism (total, LDL and HDL cholesterol and triglycerides) were determined on days 0, 3 and 6. On the same days, levels of the cholesterol synthesis indexes (lathosterol, squalene) and absorption (campesterol, sitosterol) were determined. The results were evaluated in comparison with the control set, and cirrhotic and non-cirrhotic patients were compared. At the same time, correlations of lipids and haemoglobin, hematocrit levels anduse of transfusions were evaluated. Results: The patients had significantly lower levels of total cholesterol (p < 0.001). Decrease of LDL and HDL cholesterol was not significant. Concentrations of triglycerides were normal. Decrease of lathosterol was significant (p < 0.05), but decrease in squalene, campesterol and sitosterol levels was insignificant. Comparing patients with cirrhosis and without cirrhosis showed statistically significant difference in levels of cholesterol and lathosterol (p < 0.05). Correlations did not show any statistically significant findings.
Conclusion: In patients with acute Gl bleeding, changes is lipid metabolism including alteration of the process of synthesis and absorption were proved. Therefore, hypocholesterolemia cannot be explained by blood loss only. However, more detailed studies need to be carried out.
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